ThreatLocker Protect employs a default-deny approach to block unauthorized software and only allows trusted applications to run. It uses application allowlisting to permit approved software while blocking others, ringfencing to restrict interactions between applications and sensitive resources, storage control to regulate file access, and network control to manage traffic and prevent unauthorized connections. These features work together to prevent cyber threats such as malware, ransomware, and application exploitation by limiting what applications can do and stopping non-trusted activities.