Microsoft Defender for Office 365 protects organizations against advanced email-borne threats such as phishing, business email compromise, malware, and zero-day attacks. It integrates with Microsoft 365 environments to provide multi-layered protection through features like Safe Attachments, Safe Links, anti-spoofing policies, and advanced anti-phishing capabilities. The solution includes Exchange Online Protection for basic spam and malware filtering, with higher-tier plans adding capabilities like real-time threat detection, automated incident response, threat hunting tools, attack simulation training, and integration with the broader Microsoft Defender XDR ecosystem for cross-platform threat correlation. It supports hybrid deployments and offers granular reporting and remediation tools for security teams to investigate incidents across email systems, SharePoint, OneDrive, and Microsoft Teams.