Hardware Detection and Response (HWDR) by Sepio is a cybersecurity service that operates at the Physical Layer (L1) to provide hardware-level detection and response capabilities. The solution employs a trafficless approach to detect, identify, and mitigate hardware-related threats across IT, OT, and IoT environments. The system continuously monitors hardware components, USB peripherals, network devices, and interconnected systems through physical layer-based examination techniques, protecting cyber-physical systems from hardware-based cyber threats. It provides visibility and detection capabilities where traditional traffic solutions cannot, focusing on identifying and monitoring all hardware assets throughout the network and peripheral infrastructure.